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The Europe - Africa Research Network for Evaluation of Second-line Therapy (EARNEST) is a partnership between 14 African clinical research sites and 6 European organisations. It is funded by the European and Developing Countries Clinical Trials Programme (EDCTP) and European national research funding agencies. The network conducts the EARNEST trial, the definitive clinical trial which aims to identify the best antiretroviral therapy for HIV positive individuals who need to switch antiretroviral therapy in a resource-limited setting. The trial commenced in October 2009 and has enrolled 1277 patients in 5 African countries – Malawi, Uganda, Zimbabwe, Kenya and Zambia. EARNEST also aims to build capacity for conducting clinical trials in Africa through training activities related to the trial, by supporting MSc and PhD training programmes for trial staff, and by enhancing the physical infrastructure at trial sites. It strengthens African collaborative links and communication through a programme of networking activities.

Read more about the EARNEST trial in the trial summary section.
 
     
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