Body Composition/ Bone Density Substudy

Bone fractures are occurring with greater frequency in HIV infected patients than in HIV negative controls. The prevalence of osteopenia and osteoporosis in HIV infected patients may be affected by traditional risk factors such as age and female gender, the duration of HIV infection, high HIV viral load, chronic inflammatory illness as well as the ART regimen. The body composition and bone mineral density study aims to further elucidate the role of different ART regimens on body composition and loss of bone mineral density after initiation of second-line therapy, and identify if greater losses are experienced by those randomised to NRTI-containing regimens. 181 participants were enrolled at the Infectious Disease Institute (IDI) and the Joint Clinical Research Centre (JCRC) in Kampala, Uganda. The substudy is sponsored by the Institute of Tropical Medicine in Antwerp, Belgium.

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