The University of Zimbabwe Clinical Research Centre (UZCRC) in Harare, Zimbabwe, was founded in 2002. The Centre is located at the Parirenyatwa Hospital Annex which is Zimbabwe’s premier referral hospital and one of the two teaching hospitals of the University of Zimbabwe, Harare. UZCRC is affiliated with the University of Zimbabwe and receives support from the government and competes for international research grants. There are currently 100 members of staff and volunteers working at the clinic. The clinic treats patients with HIV and related infectious diseases. As of the 1st of April 2010, there were approximately 2000 HIV positive patients on follow-up in this clinic, of whom approximately 1700 patients are currently on first-line treatment, and approximately 300 patients have been started on second-line therapy. The site has a great deal of experience in clinical research and has participated in numerous trials including DART, ARROW, ACTG(A5175; A5221; A5208; A5185; A5190) HPTN (O52) and IMPAACT (P1060). The key EARNEST site personnel are Prof. James Gita Hakim (PI), Dr Andrew Reid (Co-PI), Dr Godfrey Mursoro (Medical Officer), Ennie Chidziva (Trial manager), Gloria Tinago (Clinic Manager), Misheck Phiri (Data Manager), Vengesai Manatsa (Senior Administrator) and these are ably supported by a comprehensive and enthusiastic team.