Five EARNEST abstracts were presented at CROI 2015
The last EARNEST participants exited the trial 12 months ago and numerous analyses have been ongoing since then. Five of these analyses abstracts were submitted to and accepted for CROI 2015 which took place in Seattle, USA from 23rd to 26th February, 2015.
Dr Andrew Kambugu and Prof Nick Paton gave oral presentations on Neurocognitive function in Africans failing first-Line ART and responses to second-line and on Impact of NRTI cross-resistance on second-line PI + NRTI therapy outcomes in Africa respectively. Poster presentations were provided by Dr Cissy Kityo on Differences in Resistance Mutations in Non-B Subtypes at First-line Failure in Africa, Dr Alejandro Arenas-Pinto on Peripheral neuropathy at first-line failure and on second-line in Sub-Saharan Africa and Prof James Hakim on Second-line treatment in Sub-Saharan Africa: 144 Follow-up of the EARNEST Trial.
Thank you to the whole EARNEST trial team for making these analyses such a success!
The EARNEST Bone Mineral Baseline Data will be presented at CROI 2014
The EARNEST Bone Mineral Density substudy team will be presenting their baseline data at CROI 2014. Congratulations to the team for getting their abstract accepted.
Follow-up in EARNEST is complete
The last EARNEST participants have exited the trial on 31st January 2014. We would like to thank all EARNEST participants for their dedication to the study and for making EARNEST a success!
The data collected in EARNEST is currently being cleaned for the final analysis.
The EARNEST week 96 data was presented at IAS 2013
The EARNEST week 96 outcome data was presented at the IAS conference in Kuala Lumpur on Wednesday, 3rd July 2013. The abstract presented can be accessed via this weblink: http://pag.ias2013.org/abstracts.aspx?aid=3024 . The EARNEST network aims to publish the full week 96 EARNEST data in late 2013.
Last Face-to-Face EARNEST meetings
An EARNEST investigators' meeting and TSC meeting have taken place in Kampala, Uganda, from 1st to 3rd May 2013. These meetings are likley to be the last face-to-face EARNEST meetings and were very exciting as the week 96 outcome data was first released to the EARNEST investigators. We are looking forward to sharing the data with the wider community in the near future.
The first EARNEST participants has exited the EARNEST trial
The first EARNEST participant has exited the trial on 17th January 2013. Congratulations for completing 144 weeks of follow-up! We would like to thank all EARNEST participants for their dedication to the study and for making EARNEST a success!
EARNEST 2012 TSC Meetings
The EARNEST Trial Steering Committee (TSC) met three times in 2012. The first meeting was a face-to-face meeting held in Kampala, Uganda on 15th February 2012. This meeting was followed by meetings via telephone conference on 04th September and 4th December 2012. We would like to thank members of the EARNEST TSC for their indispensible input.
Expansion of the EARNEST TSC, January 2012
The EARNEST Trial Steering Committee (TSC) has recently been expanded and now includes thirteen members, seven of which are completely impendent of the EARNEST trial. The expertise from the different members of the TSC varies from clinical expertise to invaluable experience in public health and community work. The knowledge and experience shared among the different members of the TSC has been extremely beneficial to the trial.
EARNEST Investigators' Meeting, 13th-14th February 2012
A very interactive 2 day Investigators’ Meeting was held in Kampala, Uganda from 13th to 14th February 2012. It was the first meeting since EARNEST was closed to recruitment and served to discuss baseline data, all aspects associated with follow-up in EARNEST, after trial issues, EARNEST networking and capacity activities and substudies that are being conducted as part of the EARNEST trial. The meeting was attended by representatives from all EARNEST sites, EARNEST monitors and European collaborators. We thank all of you for your great contributions and are looking forward to seeing you again in 2013.
EARNEST Recruitment Closed on 29 April 2011
We are pleased to announce that recruitment into EARNEST closed on midnight on Friday, 29 April 2011. At the time an impressive 1277 patients had been enrolled into EARNEST.
Trial Steering Committee (TSC) Meeting, 30 March 2011
A EARNEST TSC telephone conference was held on Wednesday, 30 March 2011 to review the progress of the trial. The TSC was very pleased that over 1000 patients had been recruited to date and congratulated all sites for this major achievement
1000th Patient Randomised on Tuesday, 29 March 2011
EARNEST has passed the next major recruitment barrier and over 1000 patients have been recruited to date.
Congratulations to the team at Nsambya Hospital, Kampala and to everyone who has contributed to us reaching this important milestone. We have just 200 patients left to recruit and are postive that the target of 1200 patients will be met by end of April.
800th Patient Randomised on Tuesday, 22 February 2011
We are pleased to announce the 800th patient was recruited into the trial on Tuesday, the 22nd of February 2011 at IDI, Uganda - Congratulations to the site for helping the trial achieve another important milestone.
600th Patient Randomised on Thursday, 16 December 2010
The 600th patient was recruited into the trial on Thursday, 16 December 2010 at JCRC Gulu, Uganda - Congratulations to the site for helping the trial reach this important milestone.
EARNEST Investigator's Meeting, December 2010
A productive 2 day meeting was held on 7th and 8th December in Entebbe, Uganda with representatives from all EARNEST sites, including representatives from the new sites at Eldoret (Kenya), Mzuzu (Malawi) and Lusaka (Zambia) and from the new JCRC sites in Kakira, Kabale and Gulu (all Uganda). There were in total around 60 attendees which made for lively and interesting discussions. All new sites provided overview presentations of their sites and valuable discussions were held on trial achievements, screening and recruitment strategies, clinical cases, events and substudies. Ideas for capacity building and networking were explored and plans for the analysis of baseline data were put forward. We thank all investigators, trial managers and other members of site staff for taking part in the meeting, and look forward to the next meeting in late 2011.
EARNEST Investigator and TSC Meetings, 28-30 April 2010
Representatives from the different sites, monitors and European collaborators were meeting in Harare from the 28th to the 29th of April to discuss progress and recruitment issues, trial procedures, protocol issues, EARNEST substudies and the networking and capacity building activities. Furthermore, as part of the investigator meeting a short workshop on second-line therapy was conducted. More than 50 participants were attending the meeting and it was the first time that the trial managers and monitors of the different sites were able to meet.
The first EARNEST Trial Steering Committee (TSC) meeting was held after the investigator meeting (30 April 2010).
First Patient Randomised on Monday, 12 April 2010
On Monday, the 12th of April the first patient was randomised into EARNEST. We would like to congratulate the JCRC Kampala site for this significant achievement.
EARNEST Site Initiation Visits, 20 November 2009 to 04 December 2009
From 20th of November to the 4th of December the sites in Zimbabwe, Malawi and Uganda were visited by members of the MRC EARNEST team. During these visits site staff was trained on trial-related procedures and the readiness of each site to conduct the EARNEST study was assessed.
EARNEST Launch Meeting, Kampala, Uganda, 22-23 September 2009
The launch meeting of the EARNEST trial was held in Kampala, Uganda on the 22nd and 23rd of September 2009. Key investigators and site personnel from all eight sites, as well as representatives from the Sponsor and from European collaborators attended this meeting.